Fipronil with Permethrin, Topical

What is fipronil with permethrin, topical?

Fipronil with permethrin, topical (brand name Effitix®), is a medication used to treat and control fleas, ticks, and chewing lice in dogs and puppies 8 weeks of age and older and weighing more than 2.3 kg (5 lb). Fipronil with permethrin topical is also labeled for repelling biting flies and for repelling and killing mosquitoes. It may also be used as a treatment of sarcoptic mange in dogs.

Never use in rabbits, cats, or other small mammals as this medication is highly toxic to those species.

It may be used off label (extra label) to treat other conditions in dogs. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions very carefully, as they may be significantly different from those on the label.

How do I give my pet fipronil with permethrin?

• Fipronil with permethrin comes in a topical, spot-on form.
• All forms are applied topically (directly onto the skin).
• Follow manufacturer’s directions on applicator use.
• Part the fur at the base of the head and apply the medication directly to the skin. 
• Wash your hands after application.
• Do not allow the animal to groom or lick the application site for at least 24 hours after application.
• Avoid contact with eyes and mouth.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

This medication should start to take effect within 6 hours.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects from fipronil with permethrin?

Fipronil with permethrin may cause the following side effects:

• Redness, itching, and/or irritation at site of application
• Vomiting, diarrhea

The following reactions are rare, but if they occur, contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. The effects of this long-acting medication will last several weeks and may be prolonged in pets with kidney and/or liver dysfunction.

Are there any risk factors for this medication?

This medication should NOT BE USED in:

• Rabbits, cats, or other small mammals (e.g., rodents)
• Dogs who are allergic to any of the components
• Dogs weighing less than 2.3 kg (5 lb)
• Dogs who are less than 8 weeks of age

This medication should be USED WITH CAUTION in dogs who:

• Are weak, frail, and/or geriatric
• Are pregnant or nursing
• Are already receiving other flea and tick medication

Are there any drug interactions I should be aware of?

Certain medications should be USED WITH CAUTION when given with fipronil with permethrin, including: 

• Other flea and tick medications

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian may schedule a follow-up visit after the course of medication is complete to ensure the condition has been cleared and/or do additional testing to ensure this is the right medication for the condition present. In this case, follow your veterinarian’s directions.
• At home, monitor for any abnormal changes. If these occur, discontinue the medication and contact your veterinarian.

How do I store fipronil with permethrin?

• Store the medication in its original container at room temperature. 
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Adverse effects should also be reported to the FDA or Health Canada.